MicroRNA Profiling Reveals Distinct Signatures in Degenerative Rotator Cuff Pathologies

• DOI: 10.1002/jor.24473
• Publication Date: 2019-09-14T09:09:56Z
• Authors: Fabian Plachel; Philipp Heuberer; Renate Gehwolf; Julia Frank; Herbert Tempfer; Christine Lehner; Nadja Weissenbacher; Andrea Wagner; Moritz Weigl; Philipp Moroder; Matthias Hackl; Andreas Traweger
• Keywords: Rotator cuff injury

ABSTRACT MicroRNAs (miRNAs) have emerged as key regulators orchestrating a wide range of inflammatory and fibrotic diseases. However, the role miRNAs in degenerative shoulder joint disorders is poorly understood. The aim this explorative case‐control study was to identify pathology‐related, circulating patients with chronic rotator cuff tendinopathy tears (RCT). In 2017, 15 were prospectively enrolled assigned three groups based on diagnosed pathology: (i) no pathology, (ii) tendinopathy, (iii) RCTs. total, 14 included. Venous blood samples (“liquid biopsies”) collected from each patient serum levels 187 determined. Subsequently, change expression nine candidate verified tendon biopsy samples, who underwent arthroscopic surgery between 2015 2018. Overall, we identified several be progressively deregulated sera either or Importantly, for these candidates repression also evident biopsies harvested treated supraspinatus tear. As similar profiles determined newly systemic miRNA signature has potential novel diagnostic prognostic biomarkers pathologies. © 2019 Authors. Journal Orthopaedic Research ® published by Wiley Periodicals, Inc. behalf Society. J Orthop Res 38:202–211, 2020