Exercise improves load bearing bone structural properties in female secreted protein acidic and rich in cysteine (SPARC) null mice but not in males

• DOI: 10.1002/jor.25950
• Publication Date: 2024-08-06T13:56:48Z
• Authors: Giselle Kaneda; Dave Huang; Nathalie Pham; Alfonso R. Gonzalez; Wafa Tawackoli; Seunghwan Lee; Miyako Suzuki; Trevor J. Nelson; Juliane D. Glaeser; Magali Millecamps; Laura S. Stone; Dmitriy Sheyn; Melodie F. Metzger
• Keywords: Calvaria; Bone remodeling; Homeostasis

Secreted protein acidic and rich in cysteine (SPARC) is the most abundant glycoprotein bone thought to play a critical role remodeling homeostasis. However, effect of SPARC relation gender exercise on quality not well understood. The purpose this study was quantify differences structural biomechanical properties between calvarial femoral from male female wild-type (WT) null (SPARC