Suppression of subgingival bacteria by antimicrobial photodynamic therapy using transgingival irradiation: A randomized clinical trial

• DOI: 10.1002/jper.23-0328
• Publication Date: 2023-11-01T17:27:41Z
• Authors: Jun‐ichiro Hayashi; Kohta Ono; Yuki Iwamura; Yasuyuki Sasaki; Tasuku Ohno; Ryoma Goto; Eisaku Nishida; Genta Yamamoto; Takeshi Kikuchi; Naoya Higuchi; Akio Mitani; Mitsuo Fukuda
• Keywords: Male; Indocyanine Green; Adult; Chitosan; Photosensitizing Agents; Dental Plaque; Gingiva; Colony Count, Microbial; Middle Aged; Real-Time Polymerase Chain Reaction; Bacterial Load; 3. Good health; Photochemotherapy; Humans; Periodontal Pocket; Nanoparticles; Female; Coloring Agents; Porphyromonas gingivalis; Aged; Follow-Up Studies

Antimicrobial photodynamic therapy (aPDT) is an effective method for eradicating bacteria in periodontal therapy. Standard aPDT requires the insertion of a laser tip into pocket, which direction irradiation limited. Therefore, we devised that uses transgingival near-infrared wavelength and indocyanine green-encapsulated chitosan-coated nanoparticles as photosensitizer.