Antiglycative effect of fruit and vegetable seed extracts: inhibition of AGE formation and carbonyl‐trapping abilities

• DOI: 10.1002/jsfa.6012
• Publication Date: 2012-11-26T16:34:27Z
• Authors: Marta Mesías; Marta Navarro; Vural Gökmen; Francisco J Morales
• Keywords: Aqueous extract

Advanced glycation end-products (AGEs) are the final products derived from non-enzymatic process. AGEs involved in development of several health complications associated with diabetes and aging. Searching for anti- AGE extracts is necessary to mitigate effects age-related pathologies.The antioxidant antiglycative activities eight aqueous fruit vegetable seeds were evaluated. All seed (3.6 mg mL(-1)) exhibited anti-AGE activity protein-glucose assay, ranging 20 92% inhibition compared aminoguanidine (4.87 mmol L(-1)). Green pepper extract exerted highest activity. However, peach pomegranate protein-methylglyoxal 0 79% inhibition. Hazelnut, almond sesame not effective when methylglyoxal was promoter. Apricot appeared inhibit formation through their capacity direct trapping 1,2-dicarbonyls (IC50=0.14 mL(-1)). No relationship between phenolic compound content found. Therefore other hydrophilic constituents addition acids must be extracts.Aqueous fruits vegetables can considered prevention glycation-associated pathologies.