The prognostic significance of p53, p27kip1, p21waf1, HER‐2/neu, and Ki67 proteins expression in gastric cancer: A clinicopathological and immunohistochemical study of 121 Arab patients

• DOI: 10.1002/jso.20324
• Publication Date: 2005-08-24T18:18:06Z
• Authors: M. S. Al‐Moundhri; V. Nirmala; I. Al‐Hadabi; K. Al‐Mawaly; I. Burney; M. Al‐Nabhani; V. Thomas; S. S. Ganguly; C. Grant
• Keywords: P53 protein

Abstract Background The variability of prognosis within a pathological stage gastric cancer (GC) at presentation, underscores the need for specific biological markers to identify subgroups patients with aggressive course intensive treatment. To our knowledge, this is first study from an Arab population reporting on relationship p53, p27 kip1 , p21 waf1 HER‐2/ neu and Ki67 expression, clinicopathological features their prognostic significance. Methods Formalin‐fixed paraffin‐embedded tumors were studied by immunohistochemistry, using monoclonal antibodies Ki67. results correlated survival. Results M:F = 80:41; median age 60 years; III IV 71%; follow‐up 34.4 months. Positive expression rates Ki67, 54%, 40%, 8.3%, 70%, 12% respectively. p53 <60 years ( P 0.03), tumor size >5cm 0.01), 0.0001), 0.04). inversely T‐stage 0.008) Her‐2/ histological grade 0.04) 0.008). Univariate analysis showed that overexpression fungating infiltrative macroscopic appearance 0.02), >5 cm lymph node metastasis p T3 T4 disease overall 0.0001) adverse factors. Patients profiles (−)/p27 (+) had better survival than those (+)/p27 (−)( 0.02). On multivariate Cox regression model, 0.03) involvement 0.01) significant factors Conclusions in GC correlates characteristics independent factor. combined added value. J. Surg. Oncol. 2005;91:243–252. © 2005 Wiley‐Liss, Inc.