Characterization of natural killer and cytotoxic T‐cell immune infiltrates in pancreatic ductal adenocarcinoma

• DOI: 10.1002/jso.27581
• Publication Date: 2024-01-10T04:55:56Z
• Authors: Julia Persky; Sylvia M. Cruz; Morgan A. Darrow; Sean J. Judge; Yueju Li; Richard J. Bold; Anthony N. Karnezis; Karen E. Matsukuma; Lihong Qi; Robert J. Canter
• Keywords: Pancreatic Neoplasms; Killer Cells, Natural; 0301 basic medicine; 03 medical and health sciences; Lymphocytes, Tumor-Infiltrating; Humans; CD8-Positive T-Lymphocytes; Prognosis; T-Lymphocytes, Cytotoxic; Carcinoma, Pancreatic Ductal

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor response to systemic therapies, including immunotherapy. Given the immunotherapeutic potential of natural killer (NK) cells, we evaluated intratumoral NK cell infiltrates along cytotoxic T cells in PDAC determine their association patient outcomes.