Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

mTORC2 RPTOR
DOI: 10.1002/jsp2.1303 Publication Date: 2024-01-03T06:00:07Z
ABSTRACT
Low back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, prevents metabolic and degenerative diseases removing recycling damaged cellular components. Despite growing evidence autophagy occurs in disc, regulation still poorly understood.
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