Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

• DOI: 10.1002/jsp2.1303
• Publication Date: 2024-01-03T06:00:07Z
• Authors: Takashi Yurube; William J. Buchser; Zhongying Zhang; Prashanta Silwal; Michael T. Lotze; James D. Kang; Gwendolyn A. Sowa; Nam V. Vo
• Keywords: mTORC2; RPTOR

Low back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, prevents metabolic and degenerative diseases removing recycling damaged cellular components. Despite growing evidence autophagy occurs in disc, regulation still poorly understood.