Latest Progress of LIPUS in Fracture Healing

• DOI: 10.1002/jum.16403
• Publication Date: 2024-01-15T17:53:11Z
• Authors: Xin Guo; Maojiang Lv; Jie Lin; Jiang Guo; Jianjing Lin; Shun Li; Yi Sun; Xintao Zhang
• Keywords: Low-intensity pulsed ultrasound

The use of low‐intensity pulsed ultrasound (LIPUS) for promoting fracture healing has been Food and Drug Administration (FDA)‐approved since 1994 due to largely its non‐thermal effects sound flow radiation force so on. Numerous clinical animal studies have shown that LIPUS can accelerate the fresh fractures, nonunions, delayed unions in pulse mode regardless devices or circumstantial factors. Rare show limitations treating fractures with intramedullary nail fixation low patient compliance. biological effect is achieved by regulating various cellular behaviors involving mesenchymal stem/stromal cells (MSCs), osteoblasts, chondrocytes, osteoclasts dose dependency on intensity time. Specifically, promotes osteogenic differentiation MSCs through ROCK‐Cot/Tpl2‐MEK–ERK signaling. Osteoblasts, turn, respond mechanical signal integrin, angiotensin type 1 (AT1), PIEZO1 mechano‐receptors, leading production inflammatory factors such as COX‐2, MCP‐1, MIP‐1β repair. also induces CCN2 expression chondrocytes thereby coordinating bone regeneration. Finally, suppresses osteoclast gene interfering ERK/c‐Fos/NFATc1 cascade. This mini‐review revisits known mechanisms strengthens need further investigation into underlying mechanisms.