Pediatric sleep apnea and craniofacial anomalies: A population‐based case–control study

• DOI: 10.1002/lary.21093
• Publication Date: 2010-09-08T06:26:48Z
• Authors: Derek J. Lam; Christine C. Jensen; Beth A. Mueller; Jacqueline R. Starr; Michael L. Cunnin...; Edward M. Weaver
• Keywords: Birth certificate

Abstract Objective: To investigate the association between craniofacial anomalies and diagnosis with obstructive sleep apnea (OSA) in a large, population‐based sample of children. Design: Retrospective case–control study. Methods: Cases OSA (n = 1,203) were identified by International Classification Diseases‐9 codes consistent 1987–2003 Washington State inpatient discharge database among children ≤18 years age born state. For each case, five controls without 6,015) randomly selected from remaining births, frequency matched birth year. Congenital anomaly diagnoses covariates extracted data for all hospitalizations during study period linked certificate data. Multiple logistic regression was used to calculate adjusted odds ratios (OR) 95% confidence intervals (CI) associations congenital (including subgroups) OSA. Results: An strongly associated presence any (adjusted OR 38, 95%CI [24, 60]) and, particular, orofacial cleft 40, [17, 94]) Down syndrome 51, [20, 128]). less noncraniofacial malformation 4.1, [3.1, 5.3]), which may reflect relatively small effect exposure bias above. Conclusions: The is These findings persist even after control major potential biases. Parents clinicians should consider screening anomalies. Laryngoscope, 2010