Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States

• DOI: 10.1002/lary.26566
• Publication Date: 2017-03-17T09:46:48Z
• Authors: Matthew H. Stenmark; Dean Shumway; Cui Guo; Jeffrey Vainshtein; Michelle Mierzwa; Reshma Jagsi; Jennifer J. Griggs; Mousumi Banerjee
• Keywords: Adult; Male; HPV; Adolescent; Databases, Factual; clinical presentation; Otolaryngology; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Health Sciences; Humans; human papillomavirus; Oropharyngeal squamous cell carcinoma; Papillomaviridae; Aged; Neoplasm Staging; Retrospective Studies; Carcinoma; Papillomavirus Infections; Middle Aged; United States; 3. Good health; Oropharyngeal Neoplasms; Cross-Sectional Studies; National Cancer Database; Lymphatic Metastasis; Female; Lymph Nodes

Objective Much of what is known about the significance human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma derived from single‐institution retrospective studies, post hoc analyses tissue specimens clinical trials, and bank studies with a small sample size. The objective this study to investigate impact HPV on frequency presentation large, national information patients who underwent testing. Study Design Retrospective, cross‐sectional study. Methods We identified comprehensive 8,359 status diagnosed between 2010 2011 within National Cancer Database. Multivariable logistic regression was used assess correlates patient tumor characteristics status. Results Among carcinoma, HPV‐related United States 65.4%. associated younger age, male sex, white race ( P < 0.001). Advanced primary stage HPV‐negative disease 0.001), whereas increasing nodal burden HPV‐positive Despite less‐advanced disease, tumors were higher likelihood metastasis at Conclusion now accounts for majority newly distinct profile, supporting efforts re‐evaluate staging treatment paradigm HPV‐associated cancer. Level Evidence 4. Laryngoscope , 127:2270–2278, 2017