Changes in Eustachian Tube Mucosa in Mice After Short‐Term Tobacco and E‐cigarette Smoke Exposure

• DOI: 10.1002/lary.29887
• Publication Date: 2021-10-04T10:57:18Z
• Authors: Brian D. Nicholas; Aleksandar Kiprovski; Diandra Perez; Rohin Mehta; Michael K. Murphy; Zhenfeng Li; Alex Tampio
• Keywords: Goblet cell; Eustachian tube; Tobacco smoke

To evaluate histologic changes in middle ear and eustachian tube (ET) mucosa of mice after exposure to tobacco or electronic cigarette (e-cigarette) smoke. determine whether there were any mitigating effects application anti-IL-13 the epidermal growth factor receptor antagonist AG1478 on noted within ET mucosa.Controlled animal study.Fifty BALB/cJ randomly assigned one five groups: A control group with no smoke exposure, two groups exposed smoke, e-cigarette vapor. Within 4 weeks was infiltrated a saline hydrogel other either Anti-IL-13 AG1478. After four more animals euthanized ETs evaluated for mucosal changes.Compared significant decreases numbers goblet cells No differences cilia, mucin, squamous metaplasia noted. Neither nor AG178 significantly altered cell count smoke; however, both agents increased vapor.Short-term vapor decrease mouse mucosa. Middle resulted an increase among vapor, but not smoke.NA Laryngoscope, 132:648-654, 2022.