A Novel Effect of Allium tuncelianum Extract: Topical Application Improves Wound Healing in a Nasal Septal Perforation Rat Model

• DOI: 10.1002/lio2.70095
• Publication Date: 2025-02-11T07:44:01Z
• Authors: Doğan Çakan; Zeliha Kübra Çakan; Gülderen Yılmaz; David Yeung; Gülnur Ekşi Bona
• Keywords: Granulation tissue; Perforation

The objective of the current study was to investigate influence Allium tuncelianum (AT) extract on wound healing in a nasal septum perforation (NSP) model. Twenty-two healthy male Sprague-Dawley rats were included this and separated into two groups. A standardized NSP created each subject. 0.09% saline (control group) 25% AT solution (study delivered intranasally daily for 14 days. At end experiment, subjects sacrificed septa excised histopathological investigation. macroscopic closure rate NSP, intranasal pH, counts acute inflammatory cells, eosinophil, fibroblast, giant cell, epithelial regeneration degeneration, vascularization, granulation formation, collagen density, cartilage regeneration, degeneration examined. obtained data analyzed statistically. (p = 0.006), fibroblast number 0.003), vascularization density 0.044), tissue amount 0.022) found be significantly higher group. However, cells count lower group 0.031) < 0.05). topically may improve an experimental Consequently, local application might promising prevent formation NSP.