Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues

• DOI: 10.1002/lipd.12327
• Publication Date: 2021-11-06T05:29:49Z
• Authors: Carina P. Van Nie...; Andrea del Huerto...; Guido A. Van Nieu...; Verónica Molina; Patricia Luna Piz...
• Keywords: Linolenic acid; Nutraceutical; Lipidology; alpha-Linolenic acid; Fatty Acid Metabolism

Abstract Jacaric acid, a conjugated linolenic acid (CLNA) present in jacaranda oil (JO), is considered potent anticarcinogenic agent. Several studies have focused on its biological effects, but the metabolism once consumed not clear yet. The aim of this work was to evaluate effects two different daily doses JO serum parameters and fatty (FA) profile mice tissues after 4 weeks feeding. No significant changes body weight gain, food intake, or tissue were determined 0.7 2 ml/kg supplementation compared control animals. Significantly lower blood low‐density lipoproteins‐cholesterol (20 mg/dl) glucose (~147–148 levels detected both oil‐treated groups (31.2 165 mg/dl, respectively). Moreover, jacaric partially converted into cis 9, trans 11 linoleic (CLA) thus further incorporated tissues. Liver evidenced highest total content (1.1%–2.2%), followed by epididymal (0.7%–1.9%) mesenteric (1.4%–1.8%) fat. Lower saturated higher unsaturated control. Our results support safety potential application with functional nutraceutical propose, increasing human CLNA consumption availability CLA.