A Hydrophobic Starch Polymer for Nanoparticle‐Mediated Delivery of Docetaxel

• DOI: 10.1002/mabi.201100244
• Publication Date: 2011-12-01T09:27:12Z
• Authors: Prajakta Dandekar; Ratnesh Jain; Thomas Stauner; Brigitta Loretz; Marcus Koch; Gerhard Wenz; Claus‐Michael Lehr
• Keywords: Internalization; Hydrophobic effect

Abstract A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis characterization propyl with a controlled degree substitution to modulate the release encapsulated drug reported. application this polymer formulating nanoparticles docetaxel, an anti‐cancer agent effective against numerous types cancers but possessing intrinsic formulation difficulties described. solvent emulsification/diffusion technique optimized respect several parameters. Uptake studies these indicate their internalization by cancerous cells peri‐nuclear localization. magnified image