Combining Alginate/PVPI‐Based Film with Frequency Rhythmic Electrical Modulation System (FREMS) Technology as an Advanced Strategy for Diabetic Wounds

• DOI: 10.1002/mabi.202300349
• Publication Date: 2023-10-06T08:19:15Z
• Authors: Marco Contardi; Maria Summa; Martina Lenzuni; Luigi Miracoli; Franco Bertora; Maurizio Diaz Mendez; Athanassia Athana...; Rosalia Bertorelli
• Keywords: FREMS technology; chronic wounds; chronic wounds; electrical stimulation; FREMS technology; treating diabetic ulcers; wound dressings;; treating diabetic ulcers; electrical stimulation; 3. Good health; wound dressings

Diabetes is rising as one of the most diffused diseases century with related urgent necessity to face its systemic and local effects on patients, such cardiovascular problems, degeneration limbs, dysfunction wound healing process. The diffusion leg ulcers has been estimated be 1.51 for 1000 population, these non-resolved wounds can produce several social, economic, mental health issues in diabetic patients. At same time, people experience neuropathic pain that causes morbidity a further decrease their quality life. Here, new study presented where asodium alginate/Polyvinylpyrrolidone-Iodine complex (PVPI)-based dressing combined Frequency Rhythmic Electrical Modulation System (FREMS) technology, an established medical device treatment ulcers. produced Alginate/PVPI-based films are characterized terms morphology, chemistry, wettability, bio-/hemo-compatibility, clotting capacity. Next, used together FREMS technology mice models, synergism action closure rate anti-inflammatory properties found. Hence, how combination electrical neurostimulation devices advanced dressings approach improve chronic demonstrated.