Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time‐lapse SRµCT

• DOI: 10.1002/maco.201709514
• Publication Date: 2018-03-05T06:35:27Z
• Authors: Berit Zeller‐Plum...; Heike Helmholz; Frank Feyerabend; Thomas Dose; Fabian Wilde; Alexander Hipp; Felix Beckmann; Regine Willumeit‐...; Jörg U. Hammel
• Keywords: Degradation; Biocompatibility; Characterization

Magnesium and its alloys have in recent years emerged as a promising alternative to titanium‐based implants for medical applications due favorable degradation properties good biocompatibility. The of materials is currently investigated by studying different samples the same material at time points after medium. This study presenting high‐resolution time‐lapse investigation Mg‐2Ag culture medium using synchrotron radiation‐based micro‐computed tomography over course 5 days. design custom‐built corrosion cell bioreactor are described. computed rate days agreement with literature. SRµCT enables segmentation cracks forming layer stresses hydrogen development.