Linear Polyethyleneimine: Optimized Synthesis and Characterization – On the Way to “Pharmagrade” Batches

• DOI: 10.1002/macp.201100190
• Publication Date: 2011-06-30T18:21:19Z
• Authors: Lutz Tauhardt; Kristian Kempe; Katrin Knop; Esra Altuntaş; Michael Jäger; Stephanie Schubert; Dagmar Fischer; Ulrich S. Schubert
• Keywords: Oxazoline; Characterization

Abstract The synthesis of linear polyethyleneimine (LPEI) by acidic hydrolysis poly(2‐ethyl‐2‐oxazoline) is studied and optimized to reach the highest degree within shortest time range using a microwave synthesizer. In addition, purification procedure significantly improved; fast batch processing combined with an excellent control actual heating represents well‐suited alternative conventional on way “pharmagrade” PEI. developed protocol for preparation methyl proton‐initiated LPEIs shows high reproducibility, identity purity proven means 1 H NMR IR spectroscopy as well MALDI‐TOF‐ ESI‐Q‐TOF‐MS. magnified image