Polymer‐Protected Gold Nanoparticles for Photothermal Treatment of Ehrlich Adenocarcinoma: In Vitro and In Vivo Studies

• DOI: 10.1002/macp.202400128
• Publication Date: 2024-05-14T11:09:03Z
• Authors: Gulnur S. Tatykha...; Rysgul N. Tuleyeva; Zhanara A. Nurakh...; Nargiz N. Gizatul...; Vladimir K. Krasn...; Daulet B. Kaldybekov; Vladimir O. Aseyev; Vitaliy V. Khutor...; Sarkyt E. Kudaibe...
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract Photothermal therapy (PTT) is recognized as an effective tool for the treatment of cancer and it has attracted considerable attention scientists. In this work, gold nanospheres (AuNSs) nanorods (AuNRs) stabilized using poly( N ‐vinylpyrrolidone) (PVP), pristine gellan gum (PGG), poly(2‐ethyl‐2‐oxazoline)‐grafted (GG‐ g ‐PEtOx) are synthesized evaluated PTT agents in Ehrlich cells. The physicochemical characteristics these AuNSs AuNRs, including their surface plasmon resonance absorption spectra, size, zeta potential, aspect ratio studied UV–vis‐spectroscopy, dynamic light scattering, transmission electron microscopy, optical microscopy techniques. polymer‐protected exhibit light‐to‐heat conversion, raising temperature from 37 to 43 °C when irradiated a visible source. case AuNSs, damage cells observed following irradiation 40 days examination. However, with regard slightly lower than AuNRs. vivo experiments demonstrate that laser tumors mice after injecting leads statistically significant decrease tumor size compared those not control samples.