Multifunctional Fluorinated Copolymer Nanoparticles via a Cationic Dendritic‐Based Macromolecular RAFT‐CTA

• DOI: 10.1002/macp.202400354
• Publication Date: 2024-11-29T10:29:04Z
• Authors: Anuja Kulkarni; Mahesh Loku Yadde...; Daniel J. Cooke; Christine M. Hama...; Alex S. Flynt; Eden E. L. Tanner; Emily L. Que; Davita L. Watkins
• Keywords: Raft; Cationic polymerization

Abstract As the field of theranostics expands, an imminent need arises for multifaceted polymer‐based nanotechnologies clinical application. In this work, reversible addition‐fragmentation chain transfer (RAFT) aqueous emulsion polymerization is used to form 19 F‐containing amphiphilic hybrid block copolymers (HBCs). Employing a cationic dendritic macromolecular agent (mCTA), polymer frameworks comprised chemically distinctive blocks differing architectures (i.e., and grafted/linear) are strategically designed synthesized. media, self‐assembled nanoparticles (PNPs) formed. Their physicochemical properties their potential as biomaterials MRI applications assessed. By showcasing newly established mCTA using these resulting PNPs imaging probes, work expands design space RAFT in biomedical research, paving way development more effective versatile tools.