Reactive Polymer Coatings: A General Route to Thiol‐ene and Thiol‐yne Click Reactions

• DOI: 10.1002/marc.201200011
• Publication Date: 2012-02-20T19:26:25Z
• Authors: Jyun‐Ting Wu; Chi‐Hui Huang; Wei‐Chieh Liang; Yen‐Lin Wu; Jiashing Yu; Hsien‐Yeh Chen
• Keywords: Polymers; Surface Properties; Quinolinium Compounds; Fibrinogen; 02 engineering and technology; Alkenes; Polymerization; Alkynes; Click Chemistry; Amino Acid Sequence; Gases; Sulfhydryl Compounds; 0210 nano-technology

AbstractReactive polymer coatings were synthesized via chemical vapor deposition (CVD) polymerization process. These coatings decouple surface design from bulk properties of underlying materials and provide a facile and general route to support thiol‐ene and thiol‐yne reactions on a variety of substrate materials. Through the reported technique, surface functions can be activated through a simple design of thiol‐terminated molecules such as polyethylene glycols (PEGs) or peptides (GRGDYC), and the according biological functions were demonstrated in controlled and low‐fouling protein adsorptions as well as accurately manipulated cell attachments.