Antimicrobial Polymers of Linear and Bottlebrush Architecture: Probing the Membrane Interaction and Physicochemical Properties

• DOI: 10.1002/marc.202200288
• Publication Date: 2022-06-10T10:02:01Z
• Authors: Alain Murhimalika...; Patrycja Kielb; Marek Bekir; Anne‐Catherine Le...; Christin Radon; Sophie Laroque; Petra Wendler; Henrike M. Müller...; Matthias Hartlieb
• Keywords: Dispersity; Linear polymer

Polymeric antimicrobial peptide mimics are a promising alternative for the future management of daunting problems associated with resistance. However, development successful polymers (APs) requires careful control factors such as amphiphilic balance, molecular weight, dispersity, sequence, and architecture. While most earlier developed APs focus on random linear copolymers, advanced architectures proves to be more potent. It is recently multivalent bottlebrush improved antibacterial hemocompatibility profiles, outperforming their counterparts. Understanding rationale behind outstanding biological activity these newly antimicrobials vital further improving performance. This work investigates physicochemical properties governing differences in between using various spectroscopic microscopic techniques. Linear copolymers solvated, thermo-responsive, possess facial amphiphilicity resulting aggregations when interacting liposomes mimicking Escheria coli membranes. The adopt stable secondary conformation aqueous solution comparison conferring rapid specific binding mechanism advantageous topology seem determinant factor APs.