Conductive Antibacterial Silk Sutures for Combating Surgical Site Infections via Electrically Controlled Drug Release

• DOI: 10.1002/marc.202500238
• Publication Date: 2025-05-02T12:24:50Z
• Authors: Rui Yang; Liqin Tang; Rui Wang; Yongliang Wang; Hui Han; Jifu Mao
• Keywords: Polypyrrole; Gelatin

Abstract Current antibacterial sutures for preventing surgical site infections (SSIs) face challenges including suboptimal drug utilization efficiency and uncontrolled burst release. To address these limitations, an conductive suture with electrically controlled release system is developed in this study. Polypyrrole (PPy) doped tannic acid (TA) situ polymerized on the surface of silk precoated chitosan/gelatin (CS/GE), designated as PCG‐SS. The PCG‐SS exhibits excellent conductivity, enabling voltage‐dependent regulation TA At −0.6 V applied potential, PPy underwent electrochemical reduction decreased positive charge density, maximal release; conversely, at +0.4 V, attained oxidized state enhanced charges, strengthening electrostatic adsorption anionic achieving 80% suppression elution. Under stimulation, rates against S. aureus E. coli exceeded 90%. This work successfully validated that a PPy‐based drug‐controlled can effectively formulate programs, providing new insights into study electronically delivery systems.