Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy

• DOI: 10.1002/mc.20780
• Publication Date: 2011-04-22T17:22:14Z
• Authors: Zhongbo Liu; Xuesen Li; Anne R. Simoneau; Mahtab Jafari; Xiaolin Zi
• Keywords: Rhodiola Rosea; Growth inhibition

The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and carcinogenesis potential use anti-aging agents in chemoprevention. Rhodiola rosea, growing high altitude or cold regions the world, has been reported to have effects Drosophila. We demonstrated that R. rosea extract one its bioactive components, salidroside, inhibited growth cell lines minimal effect on nonmalignant epithelial cells TEU-2. Interestingly, salidroside component exhibited selective ability inhibit p53 knockout primary mouse embryo fibroblasts (p53-/- MEFs) compared their wild-type counterparts. inhibitory were, however, attenuated TSC2 double knock MEFs (TSC2-/-, p53-/- MEFs), protein is, at least part, required for salidroside. treatment UMUC3 resulted an increase AMP-activated kinase (AMPK)-α phosphorylation decrease 4E-BP1 phosphorylation, leading increased binding m7 GTP. These results indicate translation initiation. Furthermore, both caused significant percentage undergoing autophagy. Therefore, deserve further study as novel chemoprevention carcinogenesis.