Status dystonicus: Predictors of outcome and progression patterns of underlying disease

• DOI: 10.1002/mds.24981
• Publication Date: 2012-04-08T03:27:22Z
• Authors: Alfonso Fasano; Lucia Ricciardi; Anna Rita Bentivo...; Carlotta Canavese; Giovanna Zorzi; Igor Petrovic; Nikola Kresojevic; Vladimir S. Kostić; Marina Svetel; Norbert Kovacs; Istvan Balas; Agathe Roubertie; Devendra Mishra; Paolo Mariotti; Teresa Temudo; Nardo Nardocci
• Keywords: Tonic (physiology)

Status dystonicus (SD) is a rare, life-threatening disorder characterized by acute worsening of generalized dystonia.This study was conducted to characterize the pathogenesis, clinical course, and prognosis SD. We reviewed records six centers analyzed them together with all cases previously reported in literature.Eighty-nine episodes occurring 68 patients were studied. The majority males (64.7%), <15 years age (58.8%), had secondary dystonia as underlying condition (37.8%). mainly tonic muscle spasms (68.5%), phasic forms more common among females. Almost needed multistaged approach, surgery being most successful strategy. Neurological conditions preceding episode worsened 16.2% (ending death 10.3%).The course outcome SD highly variable; male gender prevalent phenotype predict poor outcome.