Status dystonicus: Predictors of outcome and progression patterns of underlying disease

• DOI: 10.1002/mds.24981
• Publication Date: 2012-04-08T03:27:22Z
• Authors: Alfonso Fasano; Lucia Ricciardi; Anna Rita Bentivo...; Carlotta Canavese; Giovanna Zorzi; Igor Petrovic; Nikola Kresojevic; Vladimir S. Kostić; Marina Svetel; Norbert Kovacs; Istvan Balas; Agathe Roubertie; Devendra Mishra; Paolo Mariotti; Teresa Temudo; Nardo Nardocci
• Keywords: Adult; Male; Adolescent; Muscle Relaxants, Central; Age Factors; Prognosis; 3. Good health; 03 medical and health sciences; Sex Factors; Treatment Outcome; 0302 clinical medicine; Dystonic Disorders; Child, Preschool; Disease Progression; Humans; Female; dystonia; dystonic storm; Child

AbstractBackground:Status dystonicus (SD) is a rare, life‐threatening disorder characterized by acute worsening of generalized dystonia.Methods:This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature.Results:Eighty‐nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%).Conclusions:The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome © 2012 Movement Disorder Society