Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study

• DOI: 10.1002/mds.26248
• Publication Date: 2015-06-19T13:44:10Z
• Authors: Tanya Simuni; Chelsea Caspell‐G...; Christopher Coffey; Lama M. Chahine; Shirley Lasch; Wolfgang H. Oertel; Geert Mayer; Birgit Högl; Ron Postuma; Aleksandar Videnovic; Amy Willis Amara; Ken Marek
• Keywords: Epworth Sleepiness Scale; Depression

Abstract Objective This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with matched healthy controls. Methods Data were obtained from Progression Markers Initiative, an international PD At baseline, participants assessed a wide range motor nonmotor scales, including Movement Disorder Society Unified Disease Rating Scale (MDS‐UPDRS). Excessive based on Epworth Sleepiness scale (ESS), cutoff 10. Results Four hundred twenty‐three subjects 196 controls recruited into study. Mean ESS (min, max) score 5.8 (0, 20) for 5.6 19) ( P = 0.54). Sixty‐six (15.6%) 24 (12%) had at least 10 0.28). No difference seen demographic characteristics, age onset, duration, subtype, cognitive status, or utilization sedatives between sleepiness‐positive versus negative group. The group higher MDS‐UPDRS Part I II but not III scores, depression autonomic dysfunction scores. associated marginal reduction A‐beta 0.05) alpha‐synuclein spinal fluid levels PD. Conclusions largest case control demonstrates no prevalence novo only clinical mood dysfunction. Ongoing longitudinal analyses will be essential further examine biological specifically role dopaminergic therapy. © 2015 International Parkinson