A longitudinal four‐dimensional computed tomography and cone beam computed tomography dataset for image‐guided radiation therapy research in lung cancer

• DOI: 10.1002/mp.12059
• Publication Date: 2016-12-19T11:59:02Z
• Authors: Geoffrey D. Hugo; Elisabeth Weiss; William C. Sleeman; Salim Balik; Paul J. Keall; Jun Lu; Jeffrey F. Willia...
• Keywords: Fiducial marker; Image-guided radiation therapy; Image registration

To describe in detail a dataset consisting of serial four-dimensional computed tomography (4DCT) and 4D cone beam CT (4DCBCT) images acquired during chemoradiotherapy 20 locally advanced, nonsmall cell lung cancer patients we have collected at our institution shared publicly with the research community.As part an NCI-sponsored study 82 4DCT 507 4DCBCT were population advanced undergoing radiation therapy. All subjects underwent concurrent radiochemotherapy to total dose 59.4-70.2 Gy using daily 1.8 or 2 fractions. Audio-visual biofeedback was used minimize breathing irregularity all fractions, including acquisition acquisitions subjects. Target, organs risk, implanted fiducial markers delineated by physician images. Image coordinate system origins between manipulated such way that can be simulate initial patient setup treatment position. on 16-slice helical simulator 10 phases 3 mm slice thickness simulation. In 13 subjects, 4DCTs also same scanner weekly Every day, commercial onboard CBCT scanner. An optically tracked external surrogate synchronized so each projection time stamped respiratory signal through in-house software hardware tools. Approximately 2500 projections over period 8-10 minutes half-fan mode half bow-tie filter. Using surrogate, sorted into reconstructed FDK reconstruction algorithm. Errors respiration sorting, reconstruction, carefully identified corrected.4DCT are available DICOM format structures DICOM-RT RTSTRUCT format. data stored Cancer Imaging Archive (TCIA, http://www.cancerimagingarchive.net/) as collection 4D-Lung available.Due high temporal frequency sampling, redundant (4DCT 4DCBCT) similar timepoints, oversampled 4DCBCT, markers, this support studies image-guided adaptive radiotherapy, assessment voxel trajectory variability, development validation new tools for image registration motion management.