Characterization of a novel liquid fiducial marker for multimodal image guidance in stereotactic body radiotherapy of prostate cancer

• DOI: 10.1002/mp.12860
• Publication Date: 2018-03-15T12:11:52Z
• Authors: Robin De Roover; Wouter Crijns; Kenneth Poels; Ronald Peeters; Cédric Draulans; Karin Haustermans; Tom Depuydt
• Keywords: Fiducial marker; Image-guided radiation therapy

Purpose Liquid fiducial markers have shown to be a promising alternative solid gold in terms of imaging artifact reduction, patient comfort, and compatibility with different modalities. This study aims investigate the performance novel BioXmark ® liquid marker for state‐of‐the‐art multimodal used prostate cancer ( PC a) radiotherapy, encompassing kV CT / CBCT , multiparametric MRI x‐ray imaging. In addition, automatic detection motion monitoring during treatment was investigated. Methods A total eight varying volumes (range 5–300 μL) were casted on square grid into gelatin phantom insert. cylindrical QLRAD length = 7 mm, Ø 1 mm) inserted reference. visibility streaking artifacts evaluated by placing CIRS anthropomorphic phantom. Relevant characteristics such as T2 T1 relaxation times, ADC value, relative proton density ) quantified insert next MES mapping water‐filled syringe Ex vivo images acquired resected specimen. Anterior–posterior projection obtained top an pelvic internal bony structures five positions anatomy 24 clinically relevant exposure settings. To quantify individual detection, single artificially isolated using postprocessing. Results Markers all sizes clearly visible only largest (100–300 displaying similar size marker. Artifact increased increasing volume. displayed good contrast ex T1‐weighted ‐weighted images. The not T2‐weighted image. induced chemical shift ‐map. Automated feasible high success (four positions) range 25–200 μL. None detected successfully when superimposed edge, independent their size. Conclusions is first show image‐guided radiotherapy a. Compared marker, they had favorable results both artifacts. does solely depend low value (not image) but also influenced its times. better adapted algorithms are necessary localization presence edges. Hence, provides minimally invasive (fine needles) highly applicable current treatments.