Report of the AAPM TG‐256 on the relative biological effectiveness of proton beams in radiation therapy

• DOI: 10.1002/mp.13390
• Publication Date: 2019-01-20T05:10:19Z
• Authors: Harald Paganetti; Eleanor Blakely; Alejandro Carabe‐...; David J. Carlson; Indra J. Das; Lei Dong; David Grosshans; Kathryn D. Held; Radhe Mohan; Vitali Moiseenko; Andrzej Niemierko; Robert D. Stewart; Henning Willers
• Keywords: Relative biological effectiveness

The biological effectiveness of proton beams relative to photon in radiation therapy has been taken be 1.1 throughout the history therapy. While potentially appropriate as an average value, actual (RBE) values may differ. This Task Group report outlines basic concepts RBE well biophysical interpretation and mathematical concepts. current knowledge on variations is reviewed discussed context clinical use relevance (with respect physical parameters). following task group aims were designed guide practice: Assess whether practice using a constant for protons should revised or maintained. Identifying sites treatment strategies where variable might utilized benefit. potential consequences delivering biologically weighted doses based and/or LET models implemented planning systems. Recommend experiments needed improve our understanding relationships among vitro, vivo, RBE, research required develop models. Develop recommendations minimize effects uncertainties associated with well-defined tumor types critical structures.