Patient body motion correction for dynamic cardiac PET‐CT by attenuation‐emission alignment according to projection consistency conditions

• DOI: 10.1002/mp.13419
• Publication Date: 2019-02-02T02:03:10Z
• Authors: Chad R. R. N. Hunter; Ran Klein; Adam M. Alessio; Robert A. deKemp
• Keywords: Correction for attenuation; Cardiac PET; Partial volume; Cardiac Imaging; Torso

Patient body motion is known to cause large deviations in the determination of myocardial blood flow (MBF) with errors exceeding 300%. Accurate correction for patient whole-body still a largely unsolved problem cardiac positron emission tomography (PET) imaging.This study evaluated efficacy using Natterer's formulation Helgason-Ludwig consistency conditions on two-dimensional Radon transform align computed PET projection data multiple time frames dynamic sequence purpose frame-by-frame rigid motion.The algorithm was digital NCAT phantoms realistic noise added by analytical simulator. Count rates used simulation were derived from clinical data. In addition, proof concept test measured torso phantom conducted.Motion resulted significant improvement accuracy MBF estimates, especially high count-rate acquisitions. Maximum 2 cm dropped 325% 25% and 250% global regional partial-volume correction, respectively. Median 33% 4.5% 27% 3.8%, Importantly, performed equally well compensate both early late frames.Cardiac PET-CT attenuation (CTAC) alignment effective reducing measurements due simulated motion, can be integrated into image reconstruction workflow.