Computer‐assisted beam modeling for particle therapy

• DOI: 10.1002/mp.14647
• Publication Date: 2020-12-07T10:18:51Z
• Authors: Hermann Fuchs; Alessio Elia; Andreas F. Resch; Peter Kuess; Armin Lühr; Marie Vidal; Loïc Grevillot; Dietmar Georg
• Keywords: Particle Therapy; Isocenter

Purpose To develop a computer‐driven and thus less user‐dependent method, allowing for simple straightforward generation of Monte Carlo (MC) beam model scanned proton carbon ion delivery system. Methods In first step, experimental measurements were performed energies in the available energy ranges. Data included depth dose profiles measured water spot sizes air at various isocenter distances. Using an automated regularization‐based optimization process (AUTO‐BEAM), GATE/Geant4 models respective lines generated. These obtained sequentially by using least square weighting functions with without regularization, to iteratively tune parameters energy, spread, sigma, divergence, emittance until user‐defined agreement was reached. Based on parameter tuning set energies, semi‐automatically The resulting validated all centers comparing independent laterally integrated curves air. For one representative center, three‐dimensional cubes compared simulations. method applied research as well four different clinical ions three particle therapy synchrotron or cyclotron accelerator systems: (a) MedAustron (b) University Proton Therapy Dresden, (c) Center Antoine Lacassagne Nice. Results Particle ranges MC agreed average within 0.2 mm lines. Spot (full‐width half maximum) positions differed than 0.4% from measurements. Dose calculation line better 1.7% absolute case treated protons. protons, generation, including geometry creation, data conversion, validation, possible working days. number iterations required converge, found be similar geometries types. Conclusion presented demonstrated work independently optics behavior lines, types, geometries. Furthermore, it is suitable non‐expert users requires only limited user interaction. Beam validation based systems, showed good agreement.