Assessment of breast cancer response to neoadjuvant chemotherapy based on ultrasound backscattering envelope statistics

• DOI: 10.1002/mp.15428
• Publication Date: 2021-12-26T05:29:35Z
• Authors: Ziemowit Klimonda; Piotr Karwat; Katarzyna Dobruch...; Hanna Piotrzkowsk...; Jerzy Litniewski
• Keywords: Neoadjuvant Therapy

Neo-adjuvant chemotherapy (NAC) is used in breast cancer before tumor surgery to reduce the size of and risk spreading. Monitoring effects NAC important because a number cases response therapy poor requires change treatment. A new method that uses quantitative ultrasound assess has been presented. The aim was detect unresponsive tumors at an early stage treatment.The assumes scattering different for responsive nonresponsive tumors. assessment based on differences between histograms echo amplitude recorded from after each dose tissue phantom, estimated using Kolmogorov-Smirnov statistics (KSS) symmetrical Kullback-Leibler divergence (KLD). After therapy, were resected histopathologically evaluated. percentage residual malignant cells determined basis assessing response. data set included obtained 37 performance methods assessed by means area under receiver operating characteristic curve (AUC).For responding tumors, decrease mean KLD KSS values observed subsequent doses NAC. In nonresponding higher did not courses. Classification or parameters allowed first drug, with AUC equal 0.83 ±$\pm$ 0.06 0.84 0.07, respectively. third dose, increased 0.90 0.05 0.91 0.04, respectively.The results indicate potential usefulness proposed effectiveness detection cases.