Cannabis use in the United States and its impact on gastrointestinal health

• DOI: 10.1002/ncp.11111
• Publication Date: 2023-12-24T07:34:50Z
• Authors: Omayma Alshaarawy; Gokulakrishnan Ba...; Thangam Venkatesan
• Keywords: Legalization; Cyclic vomiting syndrome

Abstract In recent years, the legalization and social acceptability of cannabis use have increased in United States. Concurrently, prevalence has continued to rise, products diversified. There are growing concerns regarding health effects regular high‐potency use, new research shed light on its potentially negative effects. Here, we review evidence gastrointestinal (GI) cannabinoids. Dysregulation endocannabinoid system might contribute various GI disorders, including irritable bowel syndrome cyclic vomiting syndrome, endocannabinoids been found regulate visceral sensation, nausea, vomiting, gut microbiome. Cannabis shown antiemetic properties, US Food Drug Administration approved cannabis‐based medications for treating chemotherapy‐induced nausea vomiting. Yet, chronic heavy linked recurrent episodes severe intractable (cannabinoid hyperemesis syndrome). Given considerable heterogeneity scientific literature, it is unclear if cannabinoid truly a distinct entity or subtype that unmasked by associated dysregulation system. The changes legalization, availability, public risk perceptions outpaced this area there need robust, prospective, large‐scale studies understand health.