Visceral fat resection in humans: Effect on insulin sensitivity, beta‐cell function, adipokines, and inflammatory markers

• DOI: 10.1002/oby.20030
• Publication Date: 2013-04-17T06:54:59Z
• Authors: Marcelo M. O. Lima; Jose C. Pareja; Sarah M. Alegre; Sylka R. Geloneze; Steven E. Kahn; Brenno D. Astiarraga; Élinton A. Chaim; Jamal Baracat; Bruno Geloneze
• Keywords: Resistin; Omentectomy; Glucose clamp technique

The visceral fat is linked to insulin resistance, the metabolic syndrome, type 2 diabetes and an increased cardiovascular risk, but it not clear whether has a causative role.Surgical resection of this depot research model address issue. Twenty premenopausal women with syndrome grade III obesity were randomized undergo Roux-en-Y gastric bypass (RYGBP) either alone or combined omentectomy. Insulin sensitivity (IS; euglycemic-hyperinsulinemic clamp), acute response glucose (AIR; intravenous tolerance test), disposition index (DI = AIR × IS measured by lipid profile, adipokine profile (leptin, adiponectin, resistin, visfatin, interleukin-6, TNF-α, MCP-1), ultra-sensitive C-reactive protein (CRP), body composition, abdominal echography assessed prior surgery 1, 6, 12 months post-surgery.Omentectomy was associated greater weight loss at all time points. improved similarly in both groups. Omentectomy lower CRP after months, did influence adipokines other parameters. Among non-diabetic subjects, omentectomy preservation baseline (as opposed deterioration control group) DI 6 months.Although enhance effect RYGBP on adipokines, secretion, loss, CRP.