A dietary phytochemical blend prevents liver damage associated with adipose tissue mobilization in ovariectomized rats

• DOI: 10.1002/oby.20907
• Publication Date: 2014-11-29T06:08:58Z
• Authors: Colette N. Miller; Jeong‐Yeh Yang; Tucker Avra; Suresh Ambati; Mary Anne Della‐Fera; Srujana Rayalam; Clifton A. Baile
• Keywords: Lipotoxicity; Phytochemical

Objective Menopausal reduction in estrogen causes increased adipose accumulation, leading many to turn dietary supplements prevent and treat such changes. Enhanced mobilization stimulated by some can increase the risk of non‐alcoholic fatty liver disease (NAFLD). Cytoprotective anti‐obesity compounds may lipotoxicity associated with mobilization. Methods A phytochemical blend was tested aged, ovariectomized rats. Rats were given AIN‐93M basal diet or a containing varying doses phytochemicals 2.4 IU/g vitamin D [diet 1: 1000 mg/kg genistein (G); 2: 500 (G), 200 resveratrol (R), quercetin (Q); 3: 400 2000 (Q)]. Results Serum free acids hepatic triglycerides elevated diets 2 3. Despite this increase, blends did not apoptotic, cell repair, remodeling gene expression. The highest dose prevented increases serum alanine aminotransferase. Conclusions Adverse effects secondary ovariectomy mitigated through inclusion aged use only help weight management menopausal women, but also NAFLD.