Human brown adipose tissue assessed by simple, noninvasive near-Infrared time-resolved spectroscopy

• DOI: 10.1002/oby.21012
• Publication Date: 2015-04-10T10:44:35Z
• Authors: Shinsuke Nirengi; Takeshi Yoneshiro; Hiroki Sugie; Masayuki Saito; Takafumi Hamaoka
• Keywords: Adult; Male; 0301 basic medicine; Spectroscopy, Near-Infrared; Time Factors; Adolescent; Temperature; Sensitivity and Specificity; Mitochondria; Hemoglobins; Young Adult; 03 medical and health sciences; Adipose Tissue, Brown; Fluorodeoxyglucose F18; Positron-Emission Tomography; Body Composition; Humans; Tomography, X-Ray Computed; Specific Gravity

Objective Human brown adipose tissue (BAT) activity has been typically evaluated by 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) combined with computed (CT). However, FDG-PET/CT serious limitations (e.g., radiation and cold exposure). This study BAT density using near-infrared time-resolved spectroscopy (NIRTRS), a simple noninvasive method of measuring the indices hemoglobin concentration [total-Hb] mitochondrial (µs′). Methods The NIRTRS parameters at 760, 800, 830 nm in supraclavicular region potentially containing were evaluated. First, compared 27°C during 2-h exposure (19°C) 18 men. Then, mean standardized uptake values (SUVmean) assessed after 29 Results There was no significant difference between 19°C. µs′ significantly correlated to SUVmean (r = 0.73 r 0.64, respectively). A receiver operating characteristic analysis revealed that sensitivity (75.0-82.4%), specificity (91.7-100%), accuracy (82.8-86.2%) all good determine reliability. Conclusions Our novel is can reliably assess human region.