Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

• DOI: 10.1002/oby.21418
• Publication Date: 2016-02-18T19:08:58Z
• Authors: Zuzana Kovacova; William G. Tharp; Dianxin Liu; Wan Wei; Hui Xie; Sheila Collins; Richard E. Pratley
• Keywords: Pioglitazone

Objective Cardiac natriuretic peptides (NPs) bind to two receptors (NPRA‐mediator of signaling; NPRC‐clearance receptor) whose ratio, NPRR (NPRA/NPRC), determines the NP bioactivity. This study investigated relationship receptor gene expression in adipose tissue and muscle with obesity glucose intolerance. Prospectively, also assessed whether changes thermogenic markers accompanied improvements insulin sensitivity. Methods A cross‐sectional subjects a wide range BMI tolerance ( n = 50) was conducted, as well randomized 12‐week trial type 2 diabetes mellitus (T2DM) treated pioglitazone 9) or placebo 10). Results mRNA significantly lower when compared lean P ≤ 0.001). decreased progression from normal T2DM < 0.01) independently obesity. Treatment increased conjunction sensitivity increases PPARγ coactivator‐1α uncoupling protein 1 0.01). Conclusions Decreased associated obesity, intolerance, resistance. not observed for skeletal NPRR. Pharmacological improvement tied genes involved processes.