Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study

• DOI: 10.1002/oby.21422
• Publication Date: 2016-02-27T14:44:02Z
• Authors: Carlos Celis‐Morales; Cyril F.M. Marsaux; Katherine M. Livi...; Santiago Navas‐Ca...; Rodrigo San‐Crist...; Clare B. O'donovan; Hannah Forster; Clara Woolhead; Rosalind Fallaize; Anna L. Macready; Silvia Kolossa; Jacqueline Hallmann; Lydia Tsirigoti; Christina P. Lamb...; George Moschonis; Magdalena Godlewska; Agnieszka Surwiłło; Keith Grimaldi; Jildau Bouwman; Yannis Manios; Iwona Traczyk; Christian A. Drevon; Laurence D. Parnell; Hannelore Daniel; Eileen R. Gibney; Lorraine Brennan; Marianne C. Walsh; Mike Gibney; Julie A. Lovegrove; J. Alfredo Martinez; Wim H.M. Saris; John C. Mathers
• Keywords: FTO gene

Objective To examine whether the effect of FTO loci on obesity‐related traits could be modified by physical activity (PA) levels in European adults. Methods Of 1,607 Food4Me participants randomized, 1,280 were genotyped for (rs9939609) and had available PA data. was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI waist circumference (WC)] self‐reported via Internet. Results genotype associated with a higher body weight [ β : 1.09 kg per risk allele, (95% CI: 0.14‐2.04), P = 0.024], BMI 0.54 m −2 , (0.23‐0.83), < 0.0001], WC 1.07 cm, (0.24‐1.90), 0.011]. Moderate‐equivalent attenuated ( [interaction] 0.020). Among inactive individuals, increased 1.06 allele 0.024), increase substantially among active individuals (0.16 0.388). We observed similar effects 0.005): 2.72 cm but only 0.49 individuals. Conclusions attenuates WC. This may have important public health implications because genetic susceptibility to obesity presence variants reduced adopting physically lifestyle.