Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver

• DOI: 10.1002/oby.22873
• Publication Date: 2020-07-13T08:34:24Z
• Authors: Teresa Auguet; Laia Bertran; Jessica Binetti; Carmen Aguilar; Salomé Martínez; Esther Guiu‐Jurado; Fàtima Sabench; Laia Adalid; José Antonio Porras; David Riesco; Daniel Del Castillo; Cristóbal Richart
• Keywords: HES1; Steatosis

Objective This cohort study aimed to explore the relationship between Notch signaling pathway and degree of nonalcoholic fatty liver disease (NAFLD). Moreover, this intended investigate whether is related hepatic lipid metabolism Toll‐like receptors (TLRs). Methods used real‐time polymerase chain reaction analysis evaluate expression level all genes studied (Notch NOTCH1 , NOTCH2 NOTCH3 NOTCH4 transcription factors HES 1 HES5 Hes‐related repressor proteins HEY HEY2 ) in tissue from two cohorts: women with severe obesity ( n = 57) normal structure 20) or NAFLD 37). Results In NAFLD, found downregulation expression. correlated positively HES1 HEY1 N OTCH 3 . also a positive correlation sterol regulatory element–binding protein 1c SREBP1c several (encoding X nuclear receptor α variant 1, farnesoid receptor, acetyl–CoA carboxylase acid synthase, peroxisome proliferator–activated α, carnitine palmitoyltransferase O ‐octanoyltransferase, ATP‐binding cassette subfamily A member G 1). Finally, 2 TLR2 TLR4 TLR9 Conclusions Taken together, these findings suggest that ligands relation pathways could have role pathogenesis.