Candidate Angiogenesis‐Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study

• DOI: 10.1002/ohn.219
• Publication Date: 2023-01-29T15:45:05Z
• Authors: A. Erim Pamuk; M. Emre Gedik; Nilda Sutay Suslu; Gurcan Gunaydin
• Keywords: Osteopontin

Angiogenesis is indeed a vital process in the progression of carcinomas, including that larynx. Therefore, this study (AngLaC) aimed to identify candidate angiogenesis-related biomarkers laryngeal carcinoma patients.Prospective controlled cohort study.Tertiary referral center.In silico analyses genes were performed determine biomarkers. Serum levels determined via enzyme-linked immunosorbent assay patients as well an age and gender-matched control group. The associations with clinical parameters investigated.The included 60 20 healthy controls. serum osteopontin, IGFBP-3, VEGF, sVEGFR-1, VEGFR-2 significantly higher patient group (p < .001, p ≤ .01, respectively). High osteopontin sVEGFR-1 associated locoregional-recurrence = .024, .016, IGFBP-3 had highest diagnostic sensitivity (81.4%) specificity (80%) among molecules investigated .001). low poor overall-survival .037, .027, disease-specific survival rates .035, .018, respectively).High proved be prognostic terms carcinoma. sVEGFR1, VEGFR2, found increased larynx cancer compared normal population. Further studies on are required order their recurrence.