Structure of Supramers Formed by the Amphiphile Biotin‐CMG‐DOPE

• DOI: 10.1002/open.202000139
• Publication Date: 2020-06-02T19:45:57Z
• Authors: Anton Zalygin; Daria Solovyeva; Ivan Vaskan; Stephen Henry; Marcel Schaefer; Pavel Volynsky; Alexander Tuzikov; Elena Korchagina; Ivan Ryzhov; Alexey Nizovtsev; Konstantin Mochalov; Roman Efremov; Eleonora Shtykova; Vladimir Oleinikov; Nicolai Bovin
• Keywords: 0301 basic medicine; info:eu-repo/classification/ddc/540; Protein Conformation; Surface Properties; Biotin; supramers; Molecular dynamics; Molecular Dynamics Simulation; 03 medical and health sciences; Supramers; biotin; Function-spacer-lipid; function-spacer-lipid; QD1-999; amphiphiles; 0303 health sciences; Molecular dynamics simulations; Phosphatidylethanolamines; Amphiphiles; molecular dynamics simulations; Full Papers; 540; molecular dynamics; Chemistry; Streptavidin; Hydrophobic and Hydrophilic Interactions

AbstractInvited for this month's cover is the group of Prof. Nicolai Bovin from the Russian Academy of Sciences. The cover picture shows how a biotin residue initially hidden in a monolayer formed on the surface of a material by biot‐CMG‐DOPE (see top left) is pulled out of the layer by the streptavidin molecule (Str) that has come close to it (see below). This can be considered as a model of certain events (in particular, cis protein‐ligand interactions) occurring on the surface of a living cell when it is necessary to hide the ligand from undesirable interactions, but leave the possibility of its recognition by a high‐affinity protein. The picture is inspired by the legendary Yellow Submarine cartoon. Read the full text of their Full Paper at 10.1002/open.201900276.