An experimental assessment of macroscopic enzyme techniques for the autopsy demonstration of myocardial infarction

• DOI: 10.1002/path.1711270207
• Publication Date: 2005-06-21T19:12:06Z
• Authors: K. R. Anderson; A. Popple; D. J. Parker; R. Sayer; R. J. Trickey; M. J. Davies
• Keywords: Cardiac enzymes

Experimental cardiac infarction produced in dogs by coronary artery ligation has been used to investigate the value of macroscopic histochemical enzyme loss diagnosis myocardial at post-mortem. Creative phosphokinase and non-specific dehydrogenase methods gave best results but became positive only 5-6 hr after infarction. It is concluded that method limited autopsy practice.