Tumour angiogenesis in prostatic carcinoma with and without bone marrow metastasis: A morphometric study

• DOI: 10.1002/path.1711680303
• Publication Date: 2005-06-22T16:12:11Z
• Authors: Shin Wakui; Masakuni Furusato; Takaaki Itoh; Hiroshi Sasaki; Akihito Akiyama; Ikuhiro Kinoshita; Koji Asano; Takaaki Tokuda; Shigeo Aizawa; Shinichiro Ushigome
• Keywords: Male; 0301 basic medicine; Neovascularization, Pathologic; Prostatic Neoplasms; Bone Neoplasms; Immunohistochemistry; Capillaries; 3. Good health; 03 medical and health sciences; Bone Marrow; Image Processing, Computer-Assisted; Humans; Neoplasm Staging

Abstract One hundred and one cases of clinical prostatic carcinoma (PCa), primary site, were analysed to define the inter‐relationship between tumour angiogenesis, histological grade, bone marrow metastasis. Tumour angiogenesis was determined by blood capillary density ratio (BCDR; a / b ), defined as area capillaries ( ) ). The BCDR evaluated colour image analysis system employing computerized morphometrical method. A total 43 PCa with metastasis (stage D2) 58 without B, C) utilized. carcinomas classified into three groups (low, intermediate, high) using Gleason's grading system. 1 similar in each histologically graded scores. On other hand, metastasis, high score higher than those low intermediate (U‐test; P<0·001 that may provide help predicting progression regard