Over‐expression of AEG‐1 significantly associates with tumour aggressiveness and poor prognosis in human non‐small cell lung cancer

• DOI: 10.1002/path.2595
• Publication Date: 2009-06-22T14:18:26Z
• Authors: Libing Song; Wen Li; Huizhong Zhang; Wenting Liao; Ting Dai; Chunping Yu; Xiaofan Ding; Lanjun Zhang; Jun Li
• Keywords: Male; 0301 basic medicine; 0303 health sciences; Lung Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; NF-kappa B; Membrane Proteins; RNA-Binding Proteins; Middle Aged; Prognosis; 3. Good health; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Carcinoma, Non-Small-Cell Lung; Lymphatic Metastasis; Biomarkers, Tumor; Humans; Female; Neoplasm Invasiveness; Cell Adhesion Molecules; Aged; Neoplasm Staging; Signal Transduction

Astrocyte elevated gene 1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression various types of human cancers. The clinical significance biological role AEG-1 non-small cell lung (NSCLC), however, remain unclear. In the present study, we found that expression was markedly up-regulated NSCLC lines tissues at level both transcription translation. Ectopically expressed enhanced migratory invasive abilities cells, whereas knockdown endogenous by specific shRNAs significantly inhibited these abilities. function on metastasis modulation associated with activation PI3K-Akt NF-kappaB signalling pathways. Furthermore, showed high 99/200 (49.5%) paraffin-embedded archival specimens. Moreover, statistical analysis displayed significant correlation stage (p < 0.001), T classification = N 0.015), distant 0.004) differentiation 0.027). Patients higher had an overall shorter survival time, patients lower better time. Multivariate suggested might be independent prognostic indicator for patients. Taken together, our results suggest plays important aggressiveness NSCLC, leading to poor outcome.