The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

• DOI: 10.1002/path.4129
• Publication Date: 2012-11-06T15:20:14Z
• Authors: Michal Cohen‐Eliav; Regina Golan‐Gerstl; Zahava Siegfried; Claus L Andersen; Kasper Thorsen; Torben F Ørntoft; David Mu; Rotem Karni
• Keywords: Splicing factor

Abstract An increasing body of evidence connects alterations in the process alternative splicing with cancer development and progression. However, a direct role factors as drivers is mostly unknown. We analysed gene copy number several colon lung tumours, found that encoding for factor SRSF6 amplified over‐expressed these cancers. Moreover, over‐expression immortal epithelial cells enhanced proliferation, protected them from chemotherapy‐induced cell death converted to be tumourigenic mice. In contrast, knock‐down lines inhibited their abilities. up‐ or down‐regulation altered tumour suppressors oncogenes generate oncogenic isoforms reduce tumour‐suppressive isoforms. Our data suggest an oncoprotein regulates proliferation survival cells.