Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin

• DOI: 10.1002/path.4572
• Publication Date: 2015-06-19T23:39:57Z
• Authors: Yihong Wang; Ren‐chin Wu; Lauren Ende Shwartz; Lisa Haley; Ming‐tse Lin; Ie‐ming Shih; Robert J Kurman
• Keywords: Histogenesis; Neoplasm

Abstract The derivation of ovarian intestinal‐type mucinous tumours is not well established. Some are derived from teratomas but the origin majority clear. It has been recently proposed that non‐germ cell group may be Brenner tumours, as association a tumour with frequently observed. In order to explore histogenesis these neoplasms, we undertook clonality analysis two components ten combined and using human androgen receptor gene ( HUMARA ) assay. All eight informative cases showed concordant X‐chromosome inactivation pattern between components, indicative shared clonal p = 0.0039). Microsatellite genotyping in five displayed an identical heterozygous paired Fallopian tube tissue, somatic origin. addition, box protein 8, highly sensitive Müllerian epithelial marker, was detected by immunohistochemistry either component any suggesting this subset does originate Müllerian‐derived epithelium. conclusion, study demonstrates there relationship different suggests some pure develop which becomes compressed obliterated expanding neoplasm. Copyright © 2015 Pathological Society Great Britain Ireland. Published John Wiley & Sons, Ltd.