The CHEVI tethering complex: facilitating special deliveries

• DOI: 10.1002/path.4785
• Publication Date: 2016-08-24T08:26:50Z
• Authors: Clare Rogerson; Paul Gissen
• Keywords: Tethering

Abstract VPS33B and VIPAR comprise the two known components of recently christened class C Homologues in Endosome–Vesicle Interaction ( CHEVI ) complex, thought to act as a tethering complex endosomal trafficking distinct from HOPS CORVET complexes mammalian cells. A recent paper The Journal Pathology further explores role biogenesis α‐granules megakaryocytes, identifying novel interactors this complex: α‐tubulin SEC22B, demonstrating that expression is required for localization SEC22B α‐granule cargo VWF proplatelets megakaryocytes. These findings advance current knowledge function together with studies other systems, corroborate its specialized delivery different cell types. Copyright © 2016 Pathological Society Great Britain Ireland. Published by John Wiley & Sons, Ltd.