Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis

• DOI: 10.1002/path.4940
• Publication Date: 2017-07-14T12:22:45Z
• Authors: Yaxiu Guo; Zhisong Zhang; Huiting Wei; Jingyu Wang; Junqiang Lv; Kai Zhang; Evan T Keller; Zhi Yao; Quan Wang
• Keywords: CDC42; PAK1; Tumor progression

Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and plays a role in prostatic carcinogenesis prostate cancer (PCa) progression. However, mechanisms through which UPEC promotes PCa development progression are unclear. Cytotoxic necrotizing factor 1 (CNF1) one most important toxins its has never been studied. We found that UPEC-secreted CNF1 promoted migration invasion cells metastasis. In vitro studies showed pro-migratory pro-invasive activity entering activating Cdc42, subsequently induced PAK1 phosphorylation up-regulation MMP-9 expression. also pulmonary metastasis xenograft mouse model these mechanisms. correlated with advanced grades human clinical tissues. These results suggest derived from an Cdc42-PAK1 signal axis up-regulating expression MMP-9. Therefore, surveillance for treatment cnf1-carrying strains may diminish thus have therapeutic impact. Copyright © 2017 Pathological Society Great Britain Ireland. Published by John Wiley & Sons, Ltd.