Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

• DOI: 10.1002/path.5205
• Publication Date: 2018-11-24T16:54:10Z
• Authors: Suzanne ABM Aarts; Tom TP Seijkens; Pascal JH Kusters; Claudia M van Tiel; Myrthe E Reiche; Myrthe den Toom; Linda Beckers; Cindy PAA van Roomen; Menno PJ de Winther; Gijs Kooij; Esther Lutgens
• Keywords: TNF Receptor-Associated Factor 6; 0301 basic medicine; Encephalomyelitis, Autoimmune, Experimental; Multiple Sclerosis; Macrophages; CD40 Ligand; Original Papers; 3. Good health; Mice, Inbred C57BL; 03 medical and health sciences; Neuritis; Immunoglobulin G; Animals; Cytokines; Female; Myelin-Oligodendrocyte Glycoprotein; CD40 Antigens; Autoantibodies; Signal Transduction

The costimulatory CD40L-CD40 dyad plays a major role in multiple sclerosis (MS). CD40 is highly expressed on MHCII