Tspan8 is expressed in breast cancer and regulates E‐cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles
0301 basic medicine
570
Tetraspanins
610
Breast Neoplasms
Extracellular Vesicles
03 medical and health sciences
Cell Line, Tumor
Brustkrebs
Biomarkers, Tumor
Animals
Humans
Neoplasm Metastasis
info:eu-repo/classification/ddc/570
biology
Carcinoma, Ductal, Breast
Cadherins
Life sciences
Original Papers
Rats
3. Good health
Carcinoma, Lobular
Carcinoma, Intraductal, Noninfiltrating
Female
ddc:570
Signal Transduction
DOI:
10.1002/path.5281
Publication Date:
2019-04-15T04:11:06Z
AUTHORS (29)
ABSTRACT
Abstract Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present first study on the expression function of breast cancer. protein was majority human primary lesions metastases brain, bone, lung, liver. In syngeneic rat model, + tumours formed multiple liver spleen metastases, while − exhibited significantly diminished ability to metastasise, indicating metastases. Addressing underlying molecular mechanisms, we discovered that can mediate up‐regulation E‐cadherin down‐regulation Twist, p120‐catenin, β‐catenin target genes accompanied by change cell phenotype, resembling mesenchymal–epithelial transition. Furthermore, cells enhanced cell–cell adhesion, motility, decreased sensitivity irradiation. As regulator content extracellular vesicles (EVs), mediated several‐fold increase EV number culture circulation tumour‐bearing animals. observed increased levels p120‐catenin these EVs; furthermore, were co‐immunoprecipitated, they may interact with each other. Altogether, our findings show presence lesion indicate its as behaviour release © 2019 The Authors. Journal Pathology published John Wiley & Sons Ltd behalf Pathological Society Great Britain Ireland.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (61)
CITATIONS (36)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....