Tspan8 is expressed in breast cancer and regulates E‐cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles

0301 basic medicine 570 Tetraspanins 610 Breast Neoplasms Extracellular Vesicles 03 medical and health sciences Cell Line, Tumor Brustkrebs Biomarkers, Tumor Animals Humans Neoplasm Metastasis info:eu-repo/classification/ddc/570 biology Carcinoma, Ductal, Breast Cadherins Life sciences Original Papers Rats 3. Good health Carcinoma, Lobular Carcinoma, Intraductal, Noninfiltrating Female ddc:570 Signal Transduction
DOI: 10.1002/path.5281 Publication Date: 2019-04-15T04:11:06Z
ABSTRACT
Abstract Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present first study on the expression function of breast cancer. protein was majority human primary lesions metastases brain, bone, lung, liver. In syngeneic rat model, + tumours formed multiple liver spleen metastases, while − exhibited significantly diminished ability to metastasise, indicating metastases. Addressing underlying molecular mechanisms, we discovered that can mediate up‐regulation E‐cadherin down‐regulation Twist, p120‐catenin, β‐catenin target genes accompanied by change cell phenotype, resembling mesenchymal–epithelial transition. Furthermore, cells enhanced cell–cell adhesion, motility, decreased sensitivity irradiation. As regulator content extracellular vesicles (EVs), mediated several‐fold increase EV number culture circulation tumour‐bearing animals. observed increased levels p120‐catenin these EVs; furthermore, were co‐immunoprecipitated, they may interact with each other. Altogether, our findings show presence lesion indicate its as behaviour release © 2019 The Authors. Journal Pathology published John Wiley & Sons Ltd behalf Pathological Society Great Britain Ireland.
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