AI‐guided histopathology predicts brain metastasis in lung cancer patients

• DOI: 10.1002/path.6263
• Publication Date: 2024-03-04T09:33:05Z
• Authors: Haowen Zhou; Mark Watson; Cory T Bernadt; Steven (Siyu) Lin; Chieh‐yu Lin; Jon H Ritter; Alexander Wein; Simon Mahler; Sid Rawal; Ramaswamy Govindan; Changhuei Yang; Richard J Cote
• Keywords: Histopathology

Brain metastases can occur in nearly half of patients with early and locally advanced (stage I-III) non-small cell lung cancer (NSCLC). There are no reliable histopathologic or molecular means to identify those who likely develop brain metastases. We sought determine if deep learning (DL) could be applied routine H&E-stained primary tumor tissue sections from stage I-III NSCLC predict the development metastasis. Diagnostic slides 158 followed for at least 5 years (Met